RNF41
Gene Ontology Biological Process
- extrinsic apoptotic signaling pathway [ISO]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- positive regulation of reactive oxygen species metabolic process [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- proteasomal protein catabolic process [ISO]
- protein autoubiquitination [ISO]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [IDA]
- regulation of MAPK cascade [ISO]
- regulation of establishment of cell polarity [IDA]
- regulation of gene expression [IDA]
- regulation of lymphocyte differentiation [IDA]
- regulation of myeloid cell differentiation [IDA]
- regulation of protein kinase B signaling [ISO]
- regulation of reactive oxygen species metabolic process [ISO]
Gene Ontology Molecular Function
BIRC6
Gene Ontology Biological Process
- labyrinthine layer development [IMP]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of endopeptidase activity [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- placenta development [IMP]
- positive regulation of cell proliferation [IMP]
- protein ubiquitination [IC, ISO]
- regulation of cell proliferation [IMP]
- regulation of cytokinesis [ISO]
- regulation of signal transduction [IBA]
- spongiotrophoblast layer development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Dexamethasone regulates expression of BRUCE/Apollon and the proliferation of neural progenitor cells.
Glucocorticoid hormones (GHs) regulate cell proliferation of neural progenitor cells (NPCs) contributing to reduction of neurogenesis after stress. We show here that dexamethasone (Dex) decreases BRUCE/Apollon (BRUCE) in cultured NPCs in a GH-receptor-dependent manner. Downregulation of BRUCE by Dex or using silencing RNA reduced the number of proliferating NPCs, whilst overexpression of BRUCE counteracted the effect of Dex. Dex also ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID