MYOG
Gene Ontology Biological Process
- cellular response to estradiol stimulus [IDA]
- cellular response to growth factor stimulus [IDA]
- cellular response to lithium ion [IDA]
- histone H3 acetylation [IDA]
- histone H4 acetylation [IDA]
- mRNA transcription from RNA polymerase II promoter [IC]
- muscle organ development [IGI]
- myotube differentiation [IGI]
- negative regulation of cell proliferation [IDA]
- ossification [IMP]
- positive regulation of cell cycle arrest [IDA]
- positive regulation of muscle atrophy [IMP]
- positive regulation of myoblast differentiation [IDA]
- positive regulation of myotube differentiation [IDA]
- positive regulation of skeletal muscle fiber development [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IC, IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of myoblast fusion [IMP]
- regulation of satellite cell proliferation [IMP]
- regulation of transcription from RNA polymerase II promoter [TAS]
- response to denervation involved in regulation of muscle adaptation [IDA]
- response to electrical stimulus involved in regulation of muscle adaptation [ISO]
- response to muscle activity involved in regulation of muscle adaptation [ISO]
- skeletal muscle fiber development [IMP]
- skeletal muscle tissue development [IDA, TAS]
- striated muscle atrophy [IMP]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC, IDA, ISO]
- chromatin DNA binding [IDA]
- core promoter binding [IDA, ISO]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
- DNA binding [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, ISO]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC, IDA, ISO]
- chromatin DNA binding [IDA]
- core promoter binding [IDA, ISO]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding transcription factor activity [IDA]
VHL
Gene Ontology Biological Process
- cell morphogenesis [NAS]
- cellular response to hypoxia [TAS]
- negative regulation of apoptotic process [NAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- positive regulation of cell differentiation [NAS]
- positive regulation of transcription, DNA-templated [IMP]
- protein stabilization [NAS]
- protein ubiquitination [IDA, IMP]
- proteolysis [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
EGLN3 prolyl hydroxylase regulates skeletal muscle differentiation and myogenin protein stability.
EGLN3, a member of the EGLN family of prolyl hydroxylases, has been shown to catalyze hydroxylation of the alpha subunit of hypoxia-inducible factor-alpha, which targets hypoxia-inducible factor-alpha for ubiquitination by a ubiquitin ligase complex containing the von Hippel-Lindau (VHL) tumor suppressor. We now report that EGLN3 levels increase during C2C12 skeletal myoblast differentiation. EGLN3 small interference RNAs and EGLN3 antisense ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VHL MYOG | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID