CASP3
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c [TAS]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [TAS]
- apoptotic signaling pathway [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- erythrocyte differentiation [IDA, TAS]
- execution phase of apoptosis [IDA, IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- hippo signaling [TAS]
- intrinsic apoptotic signaling pathway [TAS]
- keratinocyte differentiation [IBA]
- negative regulation of apoptotic process [IGI]
- neuron differentiation [IBA]
- neurotrophin TRK receptor signaling pathway [TAS]
- platelet formation [TAS]
- positive regulation of apoptotic process [TAS]
- proteolysis [IDA]
- regulation of apoptotic process [TAS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- response to tumor necrosis factor [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytosol [IDA, TAS]
- nucleoplasm [TAS]
- nucleus [IDA]
- plasma membrane [TAS]
HEY2
Gene Ontology Biological Process
- Notch signaling involved in heart development [IC]
- Notch signaling pathway [ISS, TAS]
- arterial endothelial cell differentiation [ISS]
- ascending aorta morphogenesis [ISS]
- atrial septum morphogenesis [ISS]
- cardiac epithelial to mesenchymal transition [ISS]
- cardiac left ventricle morphogenesis [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac septum morphogenesis [ISS]
- cardiac ventricle morphogenesis [ISS]
- dorsal aorta morphogenesis [ISS]
- labyrinthine layer blood vessel development [ISS]
- mesenchymal cell development [ISS]
- muscular septum morphogenesis [ISS]
- negative regulation of cardiac vascular smooth muscle cell differentiation [ISS]
- negative regulation of gene expression [ISS]
- negative regulation of transcription by transcription factor localization [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [ISS]
- negative regulation of transcription initiation from RNA polymerase II promoter [IDA]
- negative regulation of transcription regulatory region DNA binding [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- outflow tract morphogenesis [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- pulmonary artery morphogenesis [ISS]
- pulmonary valve morphogenesis [ISS]
- regulation of vasculogenesis [ISS]
- smooth muscle cell differentiation [NAS]
- tricuspid valve morphogenesis [ISS]
- umbilical cord morphogenesis [ISS]
- vascular smooth muscle cell development [IEP]
- vasculogenesis [ISS]
- ventricular cardiac muscle cell development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- histone deacetylase binding [IPI]
- microsatellite binding [IDA]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISS]
- histone deacetylase binding [IPI]
- microsatellite binding [IDA]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [NAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection.
Skp1-cullin-F-box protein (SCF) is a multicomponent E3 ubiquitin (Ub) ligase that ubiquitinates a number of important biologic molecules such as p27, beta-catenin, and IkappaB for proteasomal degradation, thus regulating cell proliferation and survival. One SCF component, SAG/ROC2/Rbx2/Hrt2, a RING finger protein, was first identified as a redox-inducible protein, which, when overexpressed, inhibited apoptosis both in vitro and in vivo. We ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID