TRAF6
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [ISO]
- JNK cascade [IMP]
- T cell receptor signaling pathway [ISO]
- T-helper 1 type immune response [ISO]
- activation of NF-kappaB-inducing kinase activity [ISO]
- activation of protein kinase activity [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [ISO]
- bone remodeling [ISO]
- bone resorption [ISO]
- cell development [ISO]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [IMP]
- immune response [ISO]
- interleukin-1-mediated signaling pathway [IMP, ISO]
- myeloid dendritic cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [ISO]
- odontogenesis of dentin-containing tooth [ISO]
- organ morphogenesis [ISO]
- ossification [ISO]
- osteoclast differentiation [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO, ISS]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO, ISS]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of T cell proliferation [ISO]
- positive regulation of interleukin-12 biosynthetic process [ISO]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of interleukin-6 biosynthetic process [ISO]
- positive regulation of lipopolysaccharide-mediated signaling pathway [ISO]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein K63-linked ubiquitination [ISO, ISS]
- protein autoubiquitination [ISO]
- protein complex assembly [IMP]
- protein polyubiquitination [ISO]
- protein ubiquitination [ISO]
- regulation of immunoglobulin secretion [ISO]
- response to interleukin-1 [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS]
- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [ISO]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [ISO, ISS]
Gene Ontology Cellular Component
NUMBL
Gene Ontology Biological Process
- adherens junction organization [ISO]
- axonogenesis [ISO]
- cytokine-mediated signaling pathway [ISO, ISS]
- forebrain development [ISO]
- lateral ventricle development [ISO, ISS]
- nervous system development [ISO]
- neuroblast division in subventricular zone [ISO, ISS]
- neuroblast proliferation [ISO]
- positive regulation of dendrite morphogenesis [IMP]
- positive regulation of neurogenesis [ISO, ISS]
- protein metabolic process [ISO, ISS]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
NUMBL interacts with TRAF6 and promotes the degradation of TRAF6.
Tumor necrosis factor-associated factor 6 (TRAF6) is an essential adaptor protein for IL-1R or TLR-mediated NF-kappaB signaling pathway activation. In previous work we have found NUMBL interacts with TAB2 and negatively regulates NF-kappaB signaling pathway. Here, we report that NUMBL directly binds to TRAF6 in vivo and in vitro. NUMBL down-regulates TRAF6 protein level and shortens its half-life. Furthermore, knockdown ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID