GSK3A
Gene Ontology Biological Process
- cardiac left ventricle morphogenesis [IMP]
- cell migration [IGI]
- cellular response to insulin stimulus [ISO]
- cellular response to interleukin-3 [IDA]
- cellular response to lithium ion [IDA]
- cellular response to organic cyclic compound [IDA]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- hypermethylation of CpG island [IMP]
- insulin receptor signaling pathway [IDA]
- negative regulation of TOR signaling [IMP]
- negative regulation of cell growth involved in cardiac muscle cell development [IMP]
- negative regulation of glucose import [ISO]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of transferase activity [ISO]
- positive regulation of adrenergic receptor signaling pathway [IMP]
- positive regulation of cAMP biosynthetic process [IMP]
- positive regulation of glycogen (starch) synthase activity [IMP]
- positive regulation of heart contraction [IMP]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of systemic arterial blood pressure [IMP]
Gene Ontology Molecular Function
CTNND1
Gene Ontology Biological Process
- cell adhesion [IMP]
- epithelial cell differentiation involved in salivary gland development [IMP]
- keratinocyte differentiation [IMP]
- morphogenesis of a polarized epithelium [IMP]
- negative regulation of canonical Wnt signaling pathway [ISO]
- salivary gland morphogenesis [IMP]
- single organismal cell-cell adhesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell-cell adherens junction [IDA]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytosol [ISO]
- dendritic spine [ISO]
- extracellular vesicular exosome [ISO]
- growth cone [ISO]
- lamellipodium [IDA, ISO]
- membrane [IDA]
- midbody [ISO]
- nucleus [ISO]
- plasma membrane [IMP, ISO]
- synapse [ISO]
- tight junction [IDA]
- zonula adherens [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
Delta-catenin was first identified because of its interaction with presenilin-1, and its aberrant expression has been reported in various human tumors and in patients with Cri-du-Chat syndrome, a form of mental retardation. However, the mechanism whereby delta-catenin is regulated in cells has not been fully elucidated. We investigated the possibility that glycogen-synthase kinase-3 (GSK-3) phosphorylates delta-catenin and thus affects its ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CTNND1 GSK3A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GSK3A CTNND1 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 556123 |
Curated By
- BioGRID