BACE1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FBXO2
Gene Ontology Biological Process
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA]
- glycoprotein catabolic process [IDA]
- negative regulation of cell proliferation [ISO]
- protein ubiquitination [IDA]
- regulation of protein ubiquitination [IDA]
- ubiquitin-dependent protein catabolic process [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
SCFFbx2-E3-ligase-mediated degradation of BACE1 attenuates Alzheimer's disease amyloidosis and improves synaptic function.
BACE1 (β-secretase) plays a central role in the β-amyloidogenesis of Alzheimer's disease (AD). The ubiquitin-proteasome system, a major intracellular protein quality control system, has been implicated recently in BACE1 metabolism. We report that the SCF(Fbx2) -E3 ligase is involved in the binding and ubiquitination of BACE1 via its Trp 280 residue of F-box-associated domain. Physiologically, we found that Fbx2 was ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID