GABARAP
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DVL2
Gene Ontology Biological Process
- Wnt signaling pathway [IGI]
- Wnt signaling pathway, planar cell polarity pathway [IDA]
- canonical Wnt signaling pathway [IDA]
- canonical Wnt signaling pathway involved in regulation of cell proliferation [IDA]
- heart development [ISS]
- hippo signaling [TAS]
- neural tube closure [ISS]
- non-canonical Wnt signaling pathway [IMP]
- outflow tract morphogenesis [ISS]
- planar cell polarity pathway involved in neural tube closure [IBA]
- positive regulation of JUN kinase activity [IDA, IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- segment specification [ISS]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation.
In eukaryotic cells, autophagy is a highly conserved self-digestion process to promote cell survival in response to nutrient starvation and other metabolic stresses. Autophagy is regulated by cell signalling such as the mTOR (mammalian target of rapamycin) pathway. However, the significance of autophagy in modulation of signal transduction is unclear. Here we show that autophagy negatively regulates Wnt signalling by ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID