VCPIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
WAC
Gene Ontology Biological Process
- G1 DNA damage checkpoint [IMP]
- cellular response to DNA damage stimulus [IMP]
- histone H2B conserved C-terminal lysine ubiquitination [IMP]
- histone monoubiquitination [IMP]
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of macroautophagy [IMP]
- positive regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- nucleoplasm [IDA]
- nucleus [TAS]
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion.
Two distinct p97 membrane fusion pathways are required for Golgi biogenesis: the p97/p47 and p97/p37 pathways. VCIP135 is necessary for both pathways, while its deubiquitinating activity is required only for the p97/p47 pathway. We have now identified a novel VCIP135-binding protein, WAC. WAC localizes to the Golgi as well as the nucleus. In Golgi membranes, WAC is involved in a ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
WAC VCPIP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
WAC VCPIP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
VCPIP1 WAC | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID