VIMP
Gene Ontology Biological Process
- ER overload response [IDA, IMP]
- ER-associated ubiquitin-dependent protein catabolic process [IDA]
- cell redox homeostasis [IDA]
- cellular response to insulin stimulus [TAS]
- cellular response to lipopolysaccharide [IMP]
- cellular response to oxidative stress [IMP]
- endoplasmic reticulum unfolded protein response [IDA]
- establishment of protein localization [TAS]
- negative regulation of acute inflammatory response to antigenic stimulus [IMP]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IMP]
- negative regulation of glucose import [TAS]
- negative regulation of glycogen biosynthetic process [TAS]
- negative regulation of inflammatory response [IC]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of macrophage apoptotic process [IMP]
- negative regulation of nitric-oxide synthase biosynthetic process [IMP]
- negative regulation of tumor necrosis factor production [ISS]
- regulation of gluconeogenesis [TAS]
- regulation of nitric oxide metabolic process [IMP]
- response to glucose [IEP]
- response to redox state [IDA]
- retrograde protein transport, ER to cytosol [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KPNB1
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [TAS]
- apoptotic DNA fragmentation [TAS]
- apoptotic process [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cytokine-mediated signaling pathway [TAS]
- intracellular transport of virus [TAS]
- protein import into nucleus [IDA]
- protein import into nucleus, translocation [TAS]
- ribosomal protein import into nucleus [IDA]
- small molecule metabolic process [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Importin {beta} interacts with the ER-associated degradation machinery and promotes ubiquitination and degradation of mutant {alpha}1-antitrypsin.
The mechanism by which misfolded proteins in the endoplasmic reticulum (ER) are retrotranslocated to the cytosol for proteasomal degradation is still poorly understood. Here, we show that importin β, a well-established nucleocytoplasmic transport protein, interacts with components of the retrotranslocation complex and promotes ER-associated degradation (ERAD). Knockdown of importin β specifically inhibited the degradation of misfolded ERAD substrates, but did ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VIMP KPNB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| KPNB1 VIMP | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| VIMP KPNB1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID