FANCC
Gene Ontology Biological Process
GSTP1
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [IDA]
- common myeloid progenitor cell proliferation [IMP]
- glutathione metabolic process [IDA]
- negative regulation of ERK1 and ERK2 cascade [IDA]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of JUN kinase activity [IDA, IMP]
- negative regulation of acute inflammatory response [NAS]
- negative regulation of apoptotic process [TAS]
- negative regulation of biosynthetic process [IDA]
- negative regulation of fibroblast proliferation [IMP]
- negative regulation of interleukin-1 beta production [IDA]
- negative regulation of leukocyte proliferation [IMP]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of neutrophil aggregation [NAS]
- negative regulation of nitric-oxide synthase biosynthetic process [IDA]
- negative regulation of peroxidase activity [IDA]
- negative regulation of stress-activated MAPK cascade [IDA]
- negative regulation of tumor necrosis factor production [IDA]
- positive regulation of superoxide anion generation [IMP]
- regulation of ERK1 and ERK2 cascade [IDA]
- regulation of stress-activated MAPK cascade [IDA]
- response to reactive oxygen species [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1.
The Fanconi anemia group C protein (FANCC) plays an important role in hematopoiesis by ensuring the survival of hematopoietic progenitor cells through an unknown mechanism. We investigated the function of FANCC by identifying FANCC-binding proteins in hematopoietic cells. Here we show that glutathione S-transferase P1-1 (GSTP1) interacts with FANCC, and that overexpression of both proteins in a myeloid progenitor cell ... [more]
Throughput
- Low Throughput
Additional Notes
- Identification of Gstp1 interacting protein was performed by microsequencing analysis, not mass spectrometry
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| FANCC GSTP1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| GSTP1 FANCC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID