BAIT
TRIM32
1810045E12Rik, 3f3, BBS11, Zfp117, RP23-468K2.1
tripartite motif-containing 32
GO Process (22)
GO Function (8)
GO Component (3)
Gene Ontology Biological Process
- actin ubiquitination [IDA]
- innate immune response [ISO]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of keratinocyte apoptotic process [NAS]
- negative regulation of viral release from host cell [ISO]
- negative regulation of viral transcription [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- positive regulation of NF-kappaB transcription factor activity [IDA, ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell motility [IDA]
- positive regulation of neurogenesis [IDA]
- positive regulation of neuron differentiation [IDA]
- positive regulation of protein catabolic process [IDA]
- positive regulation of proteolysis [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- response to UV [IDA]
- response to tumor necrosis factor [IDA]
Gene Ontology Molecular Function
Mus musculus
PREY
PIAS1
2900068C24Rik, Ddxbp1, GBP
protein inhibitor of activated STAT 1
GO Process (12)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
- JAK-STAT cascade [ISA]
- mitotic S phase [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of nucleic acid-templated transcription [ISA]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein sumoylation [ISO]
- positive regulation of smooth muscle cell differentiation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein sumoylation [IDA]
- protein-DNA complex assembly [ISO]
- regulation of cell proliferation [IMP]
Gene Ontology Molecular Function
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.
Protein inhibitors of activated STATs (PIAS) family members are ubiquitin-protein isopeptide ligase-small ubiquitin-like modifier ligases for diverse transcription factors. However, the regulation of PIAS protein activity in cells is poorly understood. Previously, we reported that expression of Trim32, a RING domain ubiquitin-protein isopeptide ligase-ubiquitin ligase mutated in human limb-girdle muscular dystrophy type 2H (LGMD2H) and Bardet-Biedl syndrome, is elevated during ... [more]
J. Biol. Chem. Sep. 01, 2006; 281(35);25850-66 [Pubmed: 16816390]
Throughput
- Low Throughput
Curated By
- BioGRID