IGF1R
Gene Ontology Biological Process
- axonogenesis [ISO]
- brain development [IMP]
- epidermis development [IMP]
- establishment of cell polarity [ISO]
- exocrine pancreas development [IMP]
- immune response [ISO]
- inactivation of MAPKK activity [ISO]
- insulin-like growth factor receptor signaling pathway [IC, ISO]
- male sex determination [IMP]
- mammary gland development [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- negative regulation of protein kinase B signaling [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- neuron projection development [ISO]
- organ morphogenesis [IMP]
- peptidyl-tyrosine autophosphorylation [IDA, ISO]
- phosphatidylinositol-mediated signaling [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cytokinesis [ISO]
- positive regulation of mitosis [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of steroid hormone biosynthetic process [ISO]
- prostate gland epithelium morphogenesis [IMP]
- protein autophosphorylation [ISO]
- protein heterooligomerization [ISO]
- protein phosphorylation [IDA]
- protein tetramerization [ISO]
- regulation of JNK cascade [ISO]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [ISO]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [IPI, ISO]
- insulin-like growth factor-activated receptor activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein tyrosine kinase activity [ISO]
- G-protein alpha-subunit binding [ISO]
- identical protein binding [ISO]
- insulin binding [ISO]
- insulin receptor binding [ISO]
- insulin receptor substrate binding [ISO]
- insulin-like growth factor I binding [ISO]
- insulin-like growth factor binding [IPI, ISO]
- insulin-like growth factor-activated receptor activity [ISO]
- phosphatidylinositol 3-kinase binding [ISO]
- protein binding [IPI]
- protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
GRB10
Gene Ontology Biological Process
- insulin receptor signaling pathway [ISO]
- insulin-like growth factor receptor signaling pathway [IPI]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of glucose import [IMP]
- negative regulation of glycogen biosynthetic process [ISO, TAS]
- negative regulation of insulin receptor signaling pathway [IMP]
- negative regulation of phosphorylation [IDA]
- positive regulation of phosphorylation [ISO]
- positive regulation of signal transduction [IPI]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- response to insulin [ISO]
- signal transduction [TAS]
Gene Ontology Molecular Function
Co-crystal Structure
Interaction directly demonstrated at the atomic level by X-ray crystallography. Also used for NMR or Electron Microscopy (EM) structures. If there is no obvious bait-hit directionality to the interaction involving 3 or more proteins, then the co-crystallized proteins should be listed as a complex.
Publication
Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4.
In addition to inhibiting insulin receptor and IGF1R kinase activity by directly binding to the receptors, GRB10 can also negatively regulate insulin and IGF1 signaling by mediating insulin receptor and IGF1R degradation through ubiquitination. It has been shown that GRB10 can interact with the C2 domain of the E3 ubiquitin ligase NEDD4 through its Src homology 2 (SH2) domain. Therefore, ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IGF1R GRB10 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID