CDK5R1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- axon guidance [ISS, TAS]
- axonal fasciculation [ISS]
- brain development [ISS, NAS]
- cell proliferation [TAS]
- ephrin receptor signaling pathway [ISS]
- ionotropic glutamate receptor signaling pathway [ISS]
- negative regulation of transcription, DNA-templated [IMP]
- neuron cell-cell adhesion [ISS]
- neuron differentiation [ISS]
- neuron migration [ISS]
- neuron projection development [ISS]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of neuron apoptotic process [ISS]
- positive regulation of protein serine/threonine kinase activity [IDA, ISS]
- regulation of cyclin-dependent protein serine/threonine kinase activity [TAS]
- regulation of dendritic spine morphogenesis [ISS]
- regulation of neuron differentiation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- axon [ISS]
- contractile fiber [ISS]
- cytoplasm [ISS]
- cytosol [TAS]
- dendrite [ISS]
- dendritic spine [ISS]
- growth cone [ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [ISS]
- neuromuscular junction [ISS]
- neuronal cell body [ISS]
- nucleoplasm [IDA]
- nucleus [ISS]
- perinuclear region of cytoplasm [IDA]
- postsynaptic density [ISS]
NES
Gene Ontology Biological Process
- G2/M transition of mitotic cell cycle [IDA]
- brain development [ISS]
- central nervous system development [NAS]
- embryonic camera-type eye development [ISS]
- negative regulation of catalytic activity [IDA]
- negative regulation of protein binding [IDA]
- positive regulation of intermediate filament depolymerization [ISS]
- positive regulation of neural precursor cell proliferation [ISS]
- stem cell proliferation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death.
The intermediate filament protein, nestin, has been implicated as an organizer of survival-determining signaling molecules. When nestin expression was related to the sensitivity of neural progenitor cells to oxidant-induced apoptosis, nestin displayed a distinct cytoprotective effect. Oxidative stress in neuronal precursor cells led to downregulation of nestin with subsequent activation of cyclin-dependent kinase 5 (Cdk5), a crucial kinase in the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID