SYVN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
WFS1
Gene Ontology Biological Process
- ER overload response [IC, TAS]
- ER-associated ubiquitin-dependent protein catabolic process [ISS]
- activation of signaling protein activity involved in unfolded protein response [TAS]
- calcium ion homeostasis [IDA]
- cellular protein metabolic process [TAS]
- endoplasmic reticulum calcium ion homeostasis [IDA]
- endoplasmic reticulum unfolded protein response [ISS, TAS]
- glucose homeostasis [IMP]
- kidney development [IMP]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [ISS]
- negative regulation of neuron apoptotic process [IMP]
- negative regulation of programmed cell death [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [ISS]
- negative regulation of type B pancreatic cell apoptotic process [IMP]
- neurological system process [IMP]
- polyubiquitinated misfolded protein transport [ISS]
- positive regulation of calcium ion transport [IDA]
- positive regulation of growth [ISS]
- positive regulation of protein metabolic process [IDA]
- positive regulation of protein ubiquitination [ISS]
- positive regulation of proteolysis [ISS]
- protein maturation by protein folding [IC]
- protein stabilization [ISS]
- renal water homeostasis [IMP]
- response to endoplasmic reticulum stress [IDA]
- sensory perception of sound [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells.
Wolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent diabetes mellitus, caused by nonautoimmune loss of beta cells, and neurological dysfunctions. We have previously shown that mutations in the Wolfram syndrome 1 (WFS1) gene cause Wolfram syndrome and that WFS1 has a protective function against ER stress. However, it remained to be determined how WFS1 mitigates ER stress. Here we ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| WFS1 SYVN1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID