BAIT

UFD1L

UFD1

ubiquitin fusion degradation 1 like (yeast)

GO Process (2)

GO Function (2)

GO Component (1)

Gene Ontology Biological Process

skeletal system development [TAS]

ubiquitin-dependent protein catabolic process [TAS]

Gene Ontology Molecular Function

protein binding [IPI]
ubiquitin-specific protease activity [TAS]

Gene Ontology Cellular Component

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PSMD2

P97, RPN1, S2, TRAP2

proteasome (prosome, macropain) 26S subunit, non-ATPase, 2

GO Process (21)

GO Function (1)

GO Component (7)

Gene Ontology Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [TAS]

G1/S transition of mitotic cell cycle [TAS]

RNA metabolic process [TAS]

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [TAS]

antigen processing and presentation of exogenous peptide antigen via MHC class I [TAS]

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent [TAS]

antigen processing and presentation of peptide antigen via MHC class I [TAS]

apoptotic process [TAS]

cellular nitrogen compound metabolic process [TAS]

gene expression [TAS]

mRNA metabolic process [TAS]

mitotic cell cycle [TAS]

negative regulation of apoptotic process [TAS]

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

protein polyubiquitination [TAS]

regulation of apoptotic process [TAS]

regulation of cellular amino acid metabolic process [TAS]

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

small molecule metabolic process [TAS]

viral process [TAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

extracellular vesicular exosome [IDA]

nucleoplasm [TAS]

proteasome accessory complex [ISS]

proteasome complex [IDA]

proteasome regulatory particle [TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.

Chen M, Gutierrez GJ, Ronai ZA

The ubiquitin-recognition protein Ufd1 facilitates clearance of misfolded proteins through the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we report that prolonged ER stress represses Ufd1 expression to trigger cell cycle delay, which contributes to ERAD. Remarkably, down-regulation of Ufd1 enhances ubiquitination and destabilization of Skp2 mediated by the anaphase-promoting complex or cyclosome bound to Cdh1 (APC/C(Cdh1)), resulting in accumulation ... [more]

Proc. Natl. Acad. Sci. U.S.A. May. 31, 2011; 108(22);9119-24 [Pubmed: 21571647]

Throughput

Low Throughput

Curated By

BioGRID