BAIT
IMP2
SPBC11C11.02
contractile ring protein Imp2
GO Process (1)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
SID2
SPAC24B11.11c
NDR kinase Sid2
GO Process (8)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site [IMP]
- negative regulation of protein homooligomerization [IMP]
- negative regulation of protein localization to microtubule [IMP]
- positive regulation of mitotic spindle elongation [IMP]
- positive regulation of nuclear migration during mitotic telophase [IMP]
- positive regulation of septation initiation signaling [IMP]
- regulation of mitotic cytokinesis [IMP]
- septation initiation signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring.
Schizosaccharomyces pombe cdc15 homology (PCH) family members participate in many cellular processes by bridging the plasma membrane and cytoskeleton. Their F-BAR domains bind and curve membranes, whereas other domains, typically SH3 domains, are expected to provide cytoskeletal links. We tested this prevailing model of functional division in the founding member of the family, Cdc15, which is essential for cytokinesis in ... [more]
J. Cell Biol. Jan. 12, 2009; 184(1);113-27 [Pubmed: 19139265]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Curated By
- BioGRID