FANCC
Gene Ontology Biological Process
POR
Gene Ontology Biological Process
- cellular organofluorine metabolic process [ISO]
- demethylation [ISO]
- fatty acid oxidation [ISO]
- internal peptidyl-lysine acetylation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of lipase activity [ISO]
- nitrate catabolic process [ISO]
- nitric oxide catabolic process [ISO]
- oxidation-reduction process [IMP, ISO]
- positive regulation of cholesterol biosynthetic process [ISO]
- positive regulation of chondrocyte differentiation [ISO]
- positive regulation of monooxygenase activity [ISO]
- positive regulation of smoothened signaling pathway [ISO]
- positive regulation of steroid hormone biosynthetic process [ISO]
- regulation of cholesterol metabolic process [ISO]
- regulation of growth plate cartilage chondrocyte proliferation [ISO]
Gene Ontology Molecular Function- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA, ISO]
- cytochrome-b5 reductase activity, acting on NAD(P)H [ISO]
- electron carrier activity [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- hydrolase activity [ISO]
- iron-cytochrome-c reductase activity [ISO]
- nitric oxide dioxygenase activity [ISO]
- oxidoreductase activity [IMP]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
- FMN binding [ISO]
- NADP binding [ISO]
- NADPH-hemoprotein reductase activity [IBA, ISO]
- cytochrome-b5 reductase activity, acting on NAD(P)H [ISO]
- electron carrier activity [ISO]
- enzyme binding [ISO]
- flavin adenine dinucleotide binding [ISO]
- hydrolase activity [ISO]
- iron-cytochrome-c reductase activity [ISO]
- nitric oxide dioxygenase activity [ISO]
- oxidoreductase activity [IMP]
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [IBA]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Abnormal microsomal detoxification implicated in Fanconi anemia group C by interaction of the FAC protein with NADPH cytochrome P450 reductase.
The FAC protein encoded by the Fanconi anemia (FA) complementation group C gene is thought to function in the cytoplasm at a step before DNA repair. Because FA cells are susceptible to mitomycin C, we considered the possibility that FAC might interact with enzymes involved in the bioreductive activation of this drug. Here we report that FAC binds to NADPH ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| POR FANCC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID