BAIT
SLC11A2
DCT1, DMT1, NRAMP2, OK/SW-cl.20
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
GO Process (22)
GO Function (14)
GO Component (19)
Gene Ontology Biological Process
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- cadmium ion transmembrane transport [IDA]
- cation transmembrane transport [IGI]
- cellular iron ion homeostasis [TAS]
- cellular response to oxidative stress [IDA]
- cobalt ion transport [IDA]
- copper ion transmembrane transport [IDA]
- copper ion transport [IDA]
- detection of oxygen [IEP]
- ferrous iron import [IDA]
- ferrous iron transport [IDA]
- lead ion transport [IDA]
- manganese ion transmembrane transport [IDA]
- manganese ion transport [IDA]
- multicellular organismal iron ion homeostasis [IMP]
- nickel cation transmembrane transport [IDA]
- nickel cation transport [IDA]
- response to hypoxia [IEP]
- response to iron ion [IEP]
- transmembrane transport [TAS]
- vanadium ion transport [IDA]
- zinc ion transmembrane transport [IDA]
Gene Ontology Molecular Function- cadmium ion transmembrane transporter activity [IDA]
- calcium ion transmembrane transporter activity [IDA]
- chromium ion transmembrane transporter activity [IDA]
- cobalt ion transmembrane transporter activity [IDA]
- copper ion transmembrane transporter activity [IDA]
- ferrous iron transmembrane transporter activity [IDA]
- inorganic cation transmembrane transporter activity [IGI]
- lead ion transmembrane transporter activity [IDA]
- manganese ion transmembrane transporter activity [IDA]
- nickel cation transmembrane transporter activity [IDA]
- protein binding [IPI]
- solute:proton symporter activity [IDA]
- vanadium ion transmembrane transporter activity [IDA]
- zinc ion transmembrane transporter activity [IDA]
- cadmium ion transmembrane transporter activity [IDA]
- calcium ion transmembrane transporter activity [IDA]
- chromium ion transmembrane transporter activity [IDA]
- cobalt ion transmembrane transporter activity [IDA]
- copper ion transmembrane transporter activity [IDA]
- ferrous iron transmembrane transporter activity [IDA]
- inorganic cation transmembrane transporter activity [IGI]
- lead ion transmembrane transporter activity [IDA]
- manganese ion transmembrane transporter activity [IDA]
- nickel cation transmembrane transporter activity [IDA]
- protein binding [IPI]
- solute:proton symporter activity [IDA]
- vanadium ion transmembrane transporter activity [IDA]
- zinc ion transmembrane transporter activity [IDA]
Gene Ontology Cellular Component
- apical part of cell [IDA]
- apical plasma membrane [IDA]
- basal part of cell [IDA]
- cell surface [IDA]
- cytoplasm [IDA]
- cytoplasmic vesicle [IDA]
- early endosome [IDA]
- late endosome [IDA]
- late endosome membrane [IDA]
- lysosomal membrane [IDA]
- lysosome [IDA]
- membrane [IDA]
- nucleus [IDA]
- paraferritin complex [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, IMP, TAS]
- recycling endosome [IDA]
- trans-Golgi network [IDA]
- vacuole [IMP]
Homo sapiens
PREY
PARK2
AR-JP, LPRS2, PDJ, PRKN, KB-152G3.1
parkin RBR E3 ubiquitin protein ligase
GO Process (58)
GO Function (22)
GO Component (12)
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- aggresome assembly [IMP]
- cellular protein catabolic process [IMP]
- cellular response to dopamine [TAS]
- cellular response to manganese ion [TAS]
- cellular response to toxic substance [IMP]
- cellular response to unfolded protein [TAS]
- central nervous system development [TAS]
- dopamine metabolic process [TAS]
- mitochondrial fission [ISS]
- mitochondrion degradation [IMP, ISS]
- mitochondrion organization [ISS]
- negative regulation of JNK cascade [ISS]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell death [IDA]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of glucokinase activity [IDA]
- negative regulation of insulin secretion [IDA]
- negative regulation of mitochondrial fusion [ISS]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [IGI]
- negative regulation of oxidative stress-induced cell death [NAS, TAS]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of reactive oxygen species metabolic process [IGI]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- neuron cellular homeostasis [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of mitochondrial fission [ISS]
- positive regulation of mitochondrial fusion [IMP]
- positive regulation of proteasomal protein catabolic process [IGI]
- positive regulation of protein linear polyubiquitination [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K27-linked ubiquitination [TAS]
- protein K29-linked ubiquitination [TAS]
- protein K48-linked ubiquitination [IDA]
- protein K6-linked ubiquitination [TAS]
- protein K63-linked ubiquitination [IDA, TAS]
- protein autoubiquitination [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IC, IDA, NAS, TAS]
- regulation of autophagy [IDA]
- regulation of cellular response to oxidative stress [ISS]
- regulation of dopamine secretion [TAS]
- regulation of glucose metabolic process [TAS]
- regulation of lipid transport [TAS]
- regulation of mitochondrion degradation [TAS]
- regulation of mitochondrion organization [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of synaptic vesicle transport [NAS]
- response to endoplasmic reticulum stress [IMP]
- response to oxidative stress [ISS]
- zinc ion homeostasis [ISS]
Gene Ontology Molecular Function- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1.
Abnormal iron accumulation is linked to a variety of neurological disorders and may contribute to the progressive damage seen in these diseases. The biochemical processes responsible for iron accumulation are not known but are likely to entail alteration in transport into injured brain areas. The major transport protein responsible for uptake of iron is divalent metal transporter 1 (DMT1) and ... [more]
J. Neurochem. Apr. 01, 2010; 113(2);454-64 [Pubmed: 20089134]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SLC11A2 PARK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID