SRC1
Gene Ontology Biological Process
Gene Ontology Cellular Component
NUP53
Gene Ontology Biological Process
- NLS-bearing protein import into nucleus [IGI, IMP]
- nuclear pore organization [IGI]
- positive regulation of transcription, DNA-templated [IDA, IGI]
- protein import into nucleus [IGI]
- protein localization to kinetochore [IMP]
- regulation of mitosis [IMP, IPI]
- regulation of protein desumoylation [IMP, IPI]
- response to spindle checkpoint signaling [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Lumenal interactions in nuclear pore complex assembly and stability.
Nuclear pore complexes (NPCs) provide a gateway for the selective transport of macromolecules across the nuclear envelope (NE). Although we have a solid understanding of NPC composition and structure, we do not have a clear grasp of the mechanism of NPC assembly. Here, we demonstrate specific defects in nucleoporin distribution in strains lacking Heh1p and Heh2p-two conserved members of the ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- genetic complex
- quadruple mutants show increased growth defects compared to double mutants
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
NUP53 SRC1 | Positive Genetic Positive Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores. | High | 2.1413 | BioGRID | 313369 | |
SRC1 NUP53 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | Low | - | BioGRID | 560223 |
Curated By
- BioGRID