BAIT
CTR9
AA409336, Sh2bp1, Tsbp, Tsp, mKIAA0155
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
GO Process (18)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- JAK-STAT cascade [IMP]
- blastocyst growth [IGI, IMP]
- cellular response to lipopolysaccharide [IDA]
- endodermal cell fate commitment [IMP]
- histone H2B ubiquitination [ISO]
- histone H3-K4 trimethylation [IMP, ISO]
- histone monoubiquitination [ISO]
- inner cell mass cell differentiation [IMP]
- interleukin-6-mediated signaling pathway [IMP]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of histone H3-K4 methylation [IMP, ISO]
- positive regulation of histone H3-K79 methylation [ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of genetic imprinting [IMP]
- stem cell maintenance [IMP, ISO]
- trophectodermal cell differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PABPC1
PABP, Pabp1, PabpI, Pabpl1, ePAB
poly(A) binding protein, cytoplasmic 1
GO Process (4)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- gene silencing by RNA [IMP]
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [ISO]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IMP]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Pluripotent embryonic stem cells (ESCs) maintain self-renewal while ensuring a rapid response to differentiation cues. The identification of genes maintaining ESC identity is important to develop these cells for their potential therapeutic use. Here we report a genome-scale RNAi screen for a global survey of genes affecting ESC identity via alteration of Oct4 expression. Factors with the strongest effect on ... [more]
Cell Stem Cell May. 08, 2009; 4(5);403-15 [Pubmed: 19345177]
Throughput
- Low Throughput
Curated By
- BioGRID