BAIT
CTR9
AA409336, Sh2bp1, Tsbp, Tsp, mKIAA0155
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
GO Process (18)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- JAK-STAT cascade [IMP]
- blastocyst growth [IGI, IMP]
- cellular response to lipopolysaccharide [IDA]
- endodermal cell fate commitment [IMP]
- histone H2B ubiquitination [ISO]
- histone H3-K4 trimethylation [IMP, ISO]
- histone monoubiquitination [ISO]
- inner cell mass cell differentiation [IMP]
- interleukin-6-mediated signaling pathway [IMP]
- negative regulation of myeloid cell differentiation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of histone H3-K4 methylation [IMP, ISO]
- positive regulation of histone H3-K79 methylation [ISO]
- positive regulation of transcription elongation from RNA polymerase II promoter [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of genetic imprinting [IMP]
- stem cell maintenance [IMP, ISO]
- trophectodermal cell differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SFPQ
1110004P21Rik, 2810416M14Rik, 5730453G22Rik, 9030402K04Rik, AU021830, D4Ertd314e, Gm12940, OTTMUSG00000009329, PSF, REP1, RP23-153M14.2
splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)
GO Process (7)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- alternative mRNA splicing, via spliceosome [ISO]
- histone H3 deacetylation [IMP]
- negative regulation of circadian rhythm [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- regulation of circadian rhythm [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
Pluripotent embryonic stem cells (ESCs) maintain self-renewal while ensuring a rapid response to differentiation cues. The identification of genes maintaining ESC identity is important to develop these cells for their potential therapeutic use. Here we report a genome-scale RNAi screen for a global survey of genes affecting ESC identity via alteration of Oct4 expression. Factors with the strongest effect on ... [more]
Cell Stem Cell May. 08, 2009; 4(5);403-15 [Pubmed: 19345177]
Throughput
- Low Throughput
Curated By
- BioGRID