DET1
Gene Ontology Biological Process
LHY
Gene Ontology Biological Process
- circadian rhythm [IGI]
- long-day photoperiodism, flowering [IGI]
- negative regulation of circadian rhythm [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- regulation of circadian rhythm [IMP]
- regulation of transcription, DNA-templated [TAS]
- response to abscisic acid [IEP]
- response to auxin [IEP]
- response to cadmium ion [IEP]
- response to cold [IGI]
- response to ethylene [IEP]
- response to gibberellin [IEP]
- response to jasmonic acid [IEP]
- response to salicylic acid [IEP]
- response to salt stress [IEP]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Interaction of Arabidopsis DET1 with CCA1 and LHY in Mediating Transcriptional Repression in the Plant Circadian Clock.
The COP10-DET1-DDB1 (CDD) complex is an evolutionarily conserved protein complex discovered for its role in the repression of photomorphogenesis in Arabidopsis. It is important in many cellular and developmental processes in both plants and animals, but its molecular mode of action remains poorly understood. Here, we show that the CDD component DET1 possesses transcriptional repression activity and physically interacts with ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID