BAIT
GSK3B
7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3
glycogen synthase kinase 3 beta
GO Process (56)
GO Function (17)
GO Component (19)
Gene Ontology Biological Process
- ER overload response [IDA, ISO]
- Wnt signaling pathway [IGI]
- axonogenesis [IGI]
- canonical Wnt signaling pathway [IDA, ISO]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [IMP]
- cell migration [IGI]
- cell proliferation [TAS]
- cellular response to interleukin-3 [IDA]
- cellular response to mechanical stimulus [ISO]
- circadian rhythm [IMP]
- cytoskeleton organization [TAS]
- epithelial to mesenchymal transition [ISO]
- establishment of cell polarity [ISO]
- establishment or maintenance of cell polarity [ISO]
- extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- fat cell differentiation [IDA]
- glycogen metabolic process [ISO]
- hippocampus development [ISO]
- hypermethylation of CpG island [IMP]
- intracellular signal transduction [ISO]
- myoblast fusion [IDA, IGI]
- myotube differentiation [IGI]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of NFAT protein import into nucleus [ISO]
- negative regulation of apoptotic process [IMP, ISO]
- negative regulation of cardiac muscle hypertrophy [IDA]
- negative regulation of dendrite morphogenesis [ISO]
- negative regulation of neuron maturation [IGI]
- negative regulation of neuron projection development [IGI, IMP]
- negative regulation of protein binding [ISO]
- negative regulation of protein complex assembly [ISO]
- organ morphogenesis [IMP]
- peptidyl-serine phosphorylation [IDA, ISO]
- phosphorylation [IMP]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of axon extension [IGI]
- positive regulation of cell-matrix adhesion [ISO]
- positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway [IDA]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IGI]
- positive regulation of protein binding [IDA]
- positive regulation of protein complex assembly [ISO]
- positive regulation of protein export from nucleus [ISO]
- positive regulation of stem cell differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein export from nucleus [IDA]
- protein localization to microtubule [IGI]
- protein phosphorylation [IDA, IGI, IMP, ISO, ISS]
- re-entry into mitotic cell cycle [IDA]
- regulation of gene expression by genetic imprinting [IMP]
- regulation of microtubule-based process [IDA, ISO]
- regulation of neuron projection development [IGI]
- regulation of neuronal synaptic plasticity [ISO]
- superior temporal gyrus development [ISO]
Gene Ontology Molecular Function- ATP binding [ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [IPI, ISO]
- integrin binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO, ISS]
- tau protein binding [ISO]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
- ATP binding [ISO]
- NF-kappaB binding [ISO]
- RNA polymerase II transcription factor binding [ISO]
- beta-catenin binding [IPI, ISO]
- integrin binding [ISO]
- ionotropic glutamate receptor binding [ISO]
- kinase activity [ISO]
- p53 binding [ISO]
- protein binding [IPI]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, IMP, ISO, ISS]
- tau protein binding [ISO]
- tau-protein kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- beta-catenin destruction complex [IDA, ISO]
- cell body [IDA]
- centrosome [ISO]
- cytoplasm [ISO]
- cytosol [IDA, ISO]
- dendritic shaft [IDA]
- dendritic spine [ISO]
- growth cone [IDA]
- membrane [ISO]
- membrane raft [ISO]
- membrane-bounded organelle [IDA]
- neuronal cell body [IDA]
- neuronal postsynaptic density [IDA]
- nucleoplasm [ISO]
- nucleus [IDA, ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [ISO]
- protein complex [ISO]
- ribonucleoprotein complex [IDA]
Mus musculus
PREY
NFE2L2
AI194320, Nrf2, RP23-374O4.2
nuclear factor, erythroid derived 2, like 2
GO Process (24)
GO Function (10)
GO Component (7)
Gene Ontology Biological Process
- cellular response to fluid shear stress [ISO]
- cellular response to hydrogen peroxide [ISO]
- cellular response to laminar fluid shear stress [ISO]
- cellular response to oxidative stress [IDA, IMP]
- cellular response to tumor necrosis factor [ISO]
- endoplasmic reticulum unfolded protein response [IDA]
- negative regulation of cell death [ISO]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of hydrogen peroxide-induced cell death [ISO]
- negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [ISO]
- positive regulation of blood coagulation [IMP]
- positive regulation of gene expression [ISO]
- positive regulation of reactive oxygen species metabolic process [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to stress [ISO]
- positive regulation of transcription, DNA-templated [IDA, IGI]
- proteasomal ubiquitin-independent protein catabolic process [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein ubiquitination [ISO]
- regulation of embryonic development [IGI]
- regulation of removal of superoxide radicals [IMP]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription cofactor binding [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II distal enhancer sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- protein binding [IPI]
- protein domain specific binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription cofactor binding [ISO]
- transcription regulatory region sequence-specific DNA binding [ISO]
Mus musculus
Biochemical Activity (Phosphorylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.
Regulation of transcription factor Nrf2 (NF-E2-related factor 2) involves redox-sensitive proteasomal degradation via the E3 ubiquitin ligase Keap1/Cul3. However, Nrf2 is controlled by other mechanisms that have not yet been elucidated. We now show that glycogen synthase kinase 3 (GSK-3) phosphorylates a group of Ser residues in the Neh6 domain of mouse Nrf2 that overlap with an SCF/β-TrCP destruction motif ... [more]
Mol. Cell. Biol. Mar. 01, 2011; 31(6);1121-33 [Pubmed: 21245377]
Throughput
- Low Throughput
Curated By
- BioGRID