CDK4
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [ISO]
- circadian rhythm [IEP]
- lens development in camera-type eye [IEP]
- negative regulation of cell cycle arrest [ISO, ISS]
- organ regeneration [IEP]
- positive regulation of G2/M transition of mitotic cell cycle [ISO, ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of cell proliferation [IMP, ISO]
- positive regulation of cell size [IMP]
- positive regulation of fibroblast proliferation [ISO]
- positive regulation of translation [IMP]
- protein phosphorylation [ISO]
- regulation of cell cycle [ISO]
- regulation of cell proliferation [ISO]
- regulation of gene expression [ISO]
- response to drug [ISO]
- response to hyperoxia [IEP]
- response to lead ion [IMP]
- response to organic substance [IMP]
- response to testosterone [IDA]
- response to toxic substance [IEP]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RASSF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease.
Previous work showed a genetic control of cell cycle deregulation during hepatocarcinogenesis. We now evaluated in preneoplastic lesions, dysplastic nodules and hepatocellular carcinoma (HCC), chemically induced in genetically susceptible F344 and resistant Brown Norway (BN) rats, the role of cell cycle regulating proteins in the determination of a phenotype susceptible to HCC development. p21(WAF1), p27(KIP1), p57(KIP2) and p130 mRNA levels ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID