UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KRAS
Gene Ontology Biological Process
- GTP catabolic process [ISO]
- Ras protein signal transduction [ISO]
- actin cytoskeleton organization [ISO]
- cytokine-mediated signaling pathway [IMP]
- epithelial tube branching involved in lung morphogenesis [ISO]
- negative regulation of cell differentiation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of Rac protein signal transduction [ISO]
- positive regulation of cell proliferation [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of nitric-oxide synthase activity [IMP]
- positive regulation of protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of synaptic transmission, GABAergic [ISO]
- response to glucocorticoid [IEP]
- response to mineralocorticoid [IEP]
- social behavior [IEP]
- striated muscle cell differentiation [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The degradation of cell cycle regulators by SKP2/CKS1 ubiquitin ligase is genetically controlled in rodent liver cancer and contributes to determine the susceptibility to the disease.
Previous work showed a genetic control of cell cycle deregulation during hepatocarcinogenesis. We now evaluated in preneoplastic lesions, dysplastic nodules and hepatocellular carcinoma (HCC), chemically induced in genetically susceptible F344 and resistant Brown Norway (BN) rats, the role of cell cycle regulating proteins in the determination of a phenotype susceptible to HCC development. p21(WAF1), p27(KIP1), p57(KIP2) and p130 mRNA levels ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID