JAG1
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling involved in heart development [IC, IMP]
- Notch signaling pathway [IMP, NAS, TAS]
- T cell mediated immunity [IMP]
- angiogenesis [NAS]
- aorta morphogenesis [ISS]
- cardiac neural crest cell development involved in outflow tract morphogenesis [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac septum morphogenesis [ISS]
- cell fate determination [NAS]
- endocardial cushion cell development [ISS]
- endothelial cell differentiation [NAS]
- hemopoiesis [NAS]
- keratinocyte differentiation [NAS]
- myoblast differentiation [NAS]
- negative regulation of stem cell differentiation [IMP]
- nervous system development [NAS]
- neuronal stem cell maintenance [IEP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- pulmonary artery morphogenesis [IMP]
- pulmonary valve morphogenesis [IMP]
- regulation of cell migration [NAS]
- regulation of cell proliferation [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HGS
Gene Ontology Biological Process
- endosomal transport [NAS, TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane invagination [IMP]
- membrane organization [TAS]
- negative regulation of JAK-STAT cascade [IDA]
- negative regulation of cell proliferation [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of exosomal secretion [IMP]
- positive regulation of gene expression [IMP]
- protein localization to membrane [IMP]
- protein targeting to lysosome [IMP]
- regulation of protein catabolic process [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Control of Notch-ligand endocytosis by ligand-receptor interaction.
In Notch signaling, cell-bound ligands activate Notch receptors on juxtaposed cells, but the relationship between ligand endocytosis, ubiquitylation and ligand-receptor interaction remains poorly understood. To study the specific role of ligand-receptor interaction, we identified a missense mutant of the Notch ligand Jagged1 (Nodder, Ndr) that failed to interact with Notch receptors, but retained a cellular distribution that was similar to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID