BAIT

CCR4

FUN27, NUT21, CCR4-NOT core exoribonuclease subunit CCR4, L000000239, YAL021C
Component of the CCR4-NOT transcriptional complex; CCR4-NOT is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
Saccharomyces cerevisiae (S288c)
PREY

SSD1

CLA1, MCS1, RLT1, SRK1, mRNA-binding translational repressor SSD1, L000002077, YDR293C
Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional N-terminal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function
Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

RNA-binding protein Khd1 and Ccr4 deadenylase play an overlapping role in the cell wall integrity pathway in yeast.

Ito W, Li X, Irie K, Mizuno T, Irie K

The yeast RNA-binding protein Khd1/Hek2 associates with hundreds of potential mRNA targets preferentially including the mRNAs encoding proteins localized to cell wall and plasma membrane. We have previously revealed that Khd1 positively regulates expression of MTL1 mRNA encoding a membrane sensor in the cell wall integrity (CWI) pathway. However, a khd1â–³ mutation has no detectable phenotype on cell wall synthesis. ... [more]

Unknown Aug. 26, 2011; 0(0); [Pubmed: 21873511]

Throughput

  • High Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • genetic complex
  • overexpression of ssd1 rescues the growth defect of a khd1/ccr4 double mutant

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
CCR4 SSD1
Synthetic Growth Defect
Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Low-BioGRID
657767
CCR4 SSD1
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
657759

Curated By

  • BioGRID