BAIT
SIRT4
SIR2L4
sirtuin 4
GO Process (9)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [ISS]
- chromatin silencing [TAS]
- glutamine metabolic process [ISS]
- negative regulation of fatty acid oxidation [ISS]
- negative regulation of insulin secretion [IMP]
- peptidyl-lysine deacetylation [ISS]
- positive regulation of lipid biosynthetic process [ISS]
- protein ADP-ribosylation [ISS, TAS]
- tricarboxylic acid metabolic process [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A6
2, 3, AAC3, ANT, ANT 2, ANT 3, ANT3, ANT3Y, RP11-261P4.6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
GO Process (11)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
- ADP transport [NAS]
- ATP transport [NAS]
- active induction of host immune response by virus [TAS]
- cellular protein metabolic process [TAS]
- energy reserve metabolic process [TAS]
- modulation by virus of host morphology or physiology [TAS]
- protein targeting to mitochondrion [TAS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- viral life cycle [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase.
Sirtuins are homologues of the yeast transcriptional repressor Sir2p and are conserved from bacteria to humans. We report that human SIRT4 is localized to the mitochondria. SIRT4 is a matrix protein and becomes cleaved at amino acid 28 after import into mitochondria. Mass spectrometry analysis of proteins that coimmunoprecipitate with SIRT4 identified insulindegrading enzyme and the ADP/ATP carrier proteins, ANT2 ... [more]
J. Biol. Chem. Nov. 16, 2007; 282(46);33583-92 [Pubmed: 17715127]
Throughput
- Low Throughput
Curated By
- BioGRID