BAIT

UBE2I

C358B7.1, P18, UBC9, LA16c-358B7.1

ubiquitin-conjugating enzyme E2I

GO Process (8)

GO Function (9)

GO Component (6)

Gene Ontology Biological Process

cellular protein metabolic process [TAS]

cellular protein modification process [TAS]

negative regulation of transcription from RNA polymerase II promoter [IMP]

negative regulation of transcription, DNA-templated [IDA]

post-translational protein modification [TAS]

protein sumoylation [IDA, TAS]

protein ubiquitination [IBA]

ubiquitin-dependent protein catabolic process [TAS]

Gene Ontology Molecular Function

RING-like zinc finger domain binding [IPI]
SUMO transferase activity [IDA]
enzyme binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
transcription factor binding [IPI]
ubiquitin protein ligase activity [IBA]
ubiquitin protein ligase binding [IBA]
ubiquitin-protein transferase activity [TAS]

Gene Ontology Cellular Component

cytoplasm [IDA]

nucleoplasm [TAS]

synaptonemal complex [TAS]

transferase complex [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

XIAP

API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, RP1-315G1.5

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

GO Process (17)

GO Function (3)

GO Component (4)

Gene Ontology Biological Process

apoptotic process [TAS]

cellular response to DNA damage stimulus [IEP]

copper ion homeostasis [TAS]

inhibition of cysteine-type endopeptidase activity involved in apoptotic process [IBA]

intrinsic apoptotic signaling pathway [TAS]

negative regulation of apoptotic process [IMP]

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]

positive regulation of canonical Wnt signaling pathway [IMP]

positive regulation of protein linear polyubiquitination [IDA]

positive regulation of protein ubiquitination [IDA]

protein ubiquitination [IDA]

regulation of BMP signaling pathway [TAS]

regulation of cell proliferation [TAS]

regulation of inflammatory response [TAS]

regulation of innate immune response [TAS]

regulation of nucleotide-binding oligomerization domain containing signaling pathway [TAS]

spindle assembly involved in mitosis [IBA]

Gene Ontology Molecular Function

cysteine-type endopeptidase inhibitor activity involved in apoptotic process [IDA]
protein binding [IPI]
ubiquitin-protein transferase activity [IDA]

Gene Ontology Cellular Component

cytoplasm [IDA]

spindle microtubule [IBA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D

Ubiquitin ligases are critical components of the ubiquitination process that determine substrate specificity and, in collaboration with E2 ubiquitin-conjugating enzymes, regulate the nature of polyubiquitin chains assembled on their substrates. Cellular inhibitor of apoptosis (c-IAP1 and c-IAP2) proteins are recruited to TNFR1-associated signalling complexes where they regulate receptor-stimulated NF-ÎºB activation through their RING domain ubiquitin ligase activity. Using a directed ... [more]

EMBO J. Dec. 15, 2010; 29(24);4198-209 [Pubmed: 21113135]

Throughput

Low Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
XIAP UBE2I	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Dynek JN (2010)	Low	-	BioGRID	-

Curated By

BioGRID