UNC13A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FBXO45
Gene Ontology Biological Process
- anterior commissure morphogenesis [IMP]
- cellular response to DNA damage stimulus [ISO]
- cerebral cortex radially oriented cell migration [IMP]
- cerebral cortex tangential migration [IMP]
- corticospinal tract morphogenesis [IMP]
- innervation [IMP]
- neuron migration [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISO]
- synapse assembly involved in innervation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.
Neurons communicate with each other through synapses. To establish the precise yet flexible connections that make up neural networks in the brain, continuous synaptic modulation is required. The ubiquitin-proteasome system of protein degradation is one of the critical mechanisms that underlie this process, playing crucial roles in the regulation of synaptic structure and function. We identified a novel ubiquitin ligase, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID