ARRB1
Gene Ontology Biological Process
- G-protein coupled receptor internalization [IMP]
- Notch signaling pathway [TAS]
- blood coagulation [TAS]
- membrane organization [TAS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of interleukin-6 production [IDA]
- negative regulation of interleukin-8 production [IDA]
- negative regulation of protein ubiquitination [IDA]
- platelet activation [TAS]
- positive regulation of ERK1 and ERK2 cascade [IDA]
- positive regulation of GTPase activity [IMP]
- positive regulation of Rho protein signal transduction [IMP]
- positive regulation of histone H4 acetylation [IMP]
- positive regulation of histone acetylation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of receptor internalization [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- post-Golgi vesicle-mediated transport [TAS]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ubiquitination [IMP]
- stress fiber assembly [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- GTPase activator activity [IMP]
- angiotensin receptor binding [IPI]
- enzyme inhibitor activity [TAS]
- histone acetyltransferase activity [IDA]
- insulin-like growth factor receptor binding [IPI]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IMP]
- ubiquitin protein ligase binding [IPI]
- GTPase activator activity [IMP]
- angiotensin receptor binding [IPI]
- enzyme inhibitor activity [TAS]
- histone acetyltransferase activity [IDA]
- insulin-like growth factor receptor binding [IPI]
- protein binding [IPI]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IMP]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
PARK2
Gene Ontology Biological Process
- adult locomotory behavior [ISS]
- aggresome assembly [IMP]
- cellular protein catabolic process [IMP]
- cellular response to dopamine [TAS]
- cellular response to manganese ion [TAS]
- cellular response to toxic substance [IMP]
- cellular response to unfolded protein [TAS]
- central nervous system development [TAS]
- dopamine metabolic process [TAS]
- mitochondrial fission [ISS]
- mitochondrion degradation [IMP, ISS]
- mitochondrion organization [ISS]
- negative regulation of JNK cascade [ISS]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell death [IDA]
- negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway [IDA, IMP]
- negative regulation of glucokinase activity [IDA]
- negative regulation of insulin secretion [IDA]
- negative regulation of mitochondrial fusion [ISS]
- negative regulation of neuron apoptotic process [IDA]
- negative regulation of neuron death [IGI]
- negative regulation of oxidative stress-induced cell death [NAS, TAS]
- negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway [IDA]
- negative regulation of protein phosphorylation [IDA]
- negative regulation of reactive oxygen species metabolic process [IGI]
- negative regulation of release of cytochrome c from mitochondria [IDA]
- neuron cellular homeostasis [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IMP]
- positive regulation of mitochondrial fission [ISS]
- positive regulation of mitochondrial fusion [IMP]
- positive regulation of proteasomal protein catabolic process [IGI]
- positive regulation of protein linear polyubiquitination [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K27-linked ubiquitination [TAS]
- protein K29-linked ubiquitination [TAS]
- protein K48-linked ubiquitination [IDA]
- protein K6-linked ubiquitination [TAS]
- protein K63-linked ubiquitination [IDA, TAS]
- protein autoubiquitination [IDA]
- protein monoubiquitination [IDA]
- protein polyubiquitination [IDA]
- protein ubiquitination [IDA, IMP]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IC, IDA, NAS, TAS]
- regulation of autophagy [IDA]
- regulation of cellular response to oxidative stress [ISS]
- regulation of dopamine secretion [TAS]
- regulation of glucose metabolic process [TAS]
- regulation of lipid transport [TAS]
- regulation of mitochondrion degradation [TAS]
- regulation of mitochondrion organization [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- regulation of synaptic vesicle transport [NAS]
- response to endoplasmic reticulum stress [IMP]
- response to oxidative stress [ISS]
- zinc ion homeostasis [ISS]
Gene Ontology Molecular Function- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
- F-box domain binding [IPI]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IPI]
- PDZ domain binding [IPI]
- SH3 domain binding [TAS]
- actin binding [IPI]
- chaperone binding [IPI]
- cullin family protein binding [IDA]
- heat shock protein binding [IPI]
- histone deacetylase binding [IPI]
- identical protein binding [IPI]
- kinase binding [IPI]
- protein binding [IPI]
- protein kinase binding [IPI]
- tubulin binding [IPI]
- ubiquitin binding [IDA]
- ubiquitin conjugating enzyme binding [IPI]
- ubiquitin protein ligase activity [IDA, NAS]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA]
- ubiquitin-specific protease binding [IPI]
- zinc ion binding [TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Ubiquitin ligase parkin promotes Mdm2-arrestin interaction but inhibits arrestin ubiquitination.
Numerous mutations in E3 ubiquitin ligase parkin were shown to associate with familial Parkinson's disease. Here we show that parkin binds arrestins, versatile regulators of cell signaling. Arrestin-parkin interaction was demonstrated by coimmunoprecipitation of endogenous proteins from brain tissue and shown to be direct using purified proteins. Parkin binding enhances arrestin interactions with another E3 ubiquitin ligase, Mdm2, apparently by ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PARK2 ARRB1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | 3465086 | |
PARK2 ARRB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
PARK2 ARRB1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID