BAIT
MDM2
ACTFS, HDMX, hdm2
MDM2 proto-oncogene, E3 ubiquitin protein ligase
GO Process (25)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- cellular response to hypoxia [IEP]
- epidermal growth factor receptor signaling pathway [TAS]
- establishment of protein localization [IDA]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of cell cycle arrest [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-lysine modification [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- protein complex assembly [IDA]
- protein destabilization [IDA]
- protein localization to nucleus [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of protein catabolic process [IDA]
- response to antibiotic [IEP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SOX4
EVI16
SRY (sex determining region Y)-box 4
GO Process (41)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- DNA damage response, detection of DNA damage [IDA]
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP]
- T cell differentiation [ISS]
- ascending aorta morphogenesis [ISS]
- atrial septum primum morphogenesis [ISS]
- canonical Wnt signaling pathway [ISS]
- cardiac right ventricle morphogenesis [ISS]
- cardiac ventricle formation [ISS]
- cellular response to glucose stimulus [ISS]
- glial cell development [ISS]
- glial cell proliferation [ISS]
- glucose homeostasis [ISS]
- heart development [ISS]
- kidney morphogenesis [ISS]
- limb bud formation [ISS]
- mitral valve morphogenesis [ISS]
- negative regulation of cell death [ISS]
- negative regulation of cell proliferation [IMP]
- negative regulation of protein export from nucleus [IMP]
- negative regulation of protein ubiquitination [IMP]
- neural tube formation [ISS]
- neuroepithelial cell differentiation [ISS]
- noradrenergic neuron differentiation [ISS]
- positive regulation of N-terminal peptidyl-lysine acetylation [IDA]
- positive regulation of Wnt signaling pathway [ISS]
- positive regulation of apoptotic process [IMP]
- positive regulation of canonical Wnt signaling pathway [ISS]
- positive regulation of cell proliferation [IMP]
- positive regulation of insulin secretion [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of translation [IMP]
- pro-B cell differentiation [ISS]
- protein stabilization [IMP]
- regulation of protein stability [IMP]
- regulation of transcription, DNA-templated [IDA]
- skeletal system development [ISS]
- spinal cord development [ISS]
- spinal cord motor neuron differentiation [ISS]
- sympathetic nervous system development [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription coactivator activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- nucleic acid binding transcription factor activity [IMP]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription regulatory region sequence-specific DNA binding [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Induction of SOX4 by DNA damage is critical for p53 stabilization and function.
DNA damage response (DDR) acts as a tumorigenesis barrier, and any defects in the DDR machinery may lead to cancer. SOX4 expression is elevated in many types of tumors; however, its role in DDR is still largely unknown. Here, we show that SOX4, a new DNA damage sensor, is required for the activation of p53 tumor suppressor in response to ... [more]
Proc. Natl. Acad. Sci. U.S.A. Mar. 10, 2009; 106(10);3788-93 [Pubmed: 19234109]
Throughput
- Low Throughput
Curated By
- BioGRID