BAIT
NKD2
Naked2
naked cuticle homolog 2 (Drosophila)
GO Process (6)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Golgi vesicle fusion to target membrane [IMP]
- negative regulation of canonical Wnt signaling pathway [IDA, IMP]
- positive regulation of establishment of protein localization to plasma membrane [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein processing [IDA]
- protein targeting to plasma membrane [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CDH1
Arc-1, CD324, CDHE, ECAD, LCAM, UVO
cadherin 1, type 1, E-cadherin (epithelial)
GO Process (17)
GO Function (7)
GO Component (16)
Gene Ontology Biological Process
- adherens junction organization [IMP, TAS]
- apoptotic process [TAS]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cellular response to indole-3-methanol [IDA]
- cellular response to lithium ion [IDA]
- establishment of protein localization to plasma membrane [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- homophilic cell adhesion via plasma membrane adhesion molecules [NAS]
- negative regulation of cell-cell adhesion [IMP]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to plasma membrane [IDA]
- regulation of immune response [TAS]
- single organismal cell-cell adhesion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- actin cytoskeleton [IDA]
- aggresome [IDA]
- apical junction complex [IDA]
- catenin complex [IDA]
- cell junction [IDA, TAS]
- cell-cell adherens junction [IDA]
- cytoplasm [IDA]
- cytoplasmic side of plasma membrane [IDA]
- extracellular region [TAS]
- extracellular vesicular exosome [IDA]
- focal adhesion [IDA]
- integral component of membrane [IDA]
- lateral plasma membrane [IDA]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, TAS]
- trans-Golgi network [IMP]
Homo sapiens
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane.
In Drosophila, naked cuticle is an inducible antagonist of the Wnt-beta-catenin pathway, likely acting at the level of Dishevelled (Dsh/Dvl), an essential component of this pathway. The mechanism by which naked cuticle and its two vertebrate orthologs, Naked1 (NKD1) and Naked2 (NKD2), inhibit Dvl function is unknown. NKD2 is myristoylated, a co-translational modification that leads to its plasma membrane localization. ... [more]
J. Biol. Chem. Apr. 30, 2010; 285(18);13561-8 [Pubmed: 20177058]
Throughput
- Low Throughput
Curated By
- BioGRID