RNF139
Gene Ontology Biological Process
- negative regulation of cell proliferation [IDA]
- negative regulation of translation [IDA]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- protein destabilization [IMP]
- protein ubiquitination [IDA, IMP]
- regulation of ER to Golgi vesicle-mediated transport [IDA]
- regulation of protein processing [IDA]
- regulation of protein ubiquitination [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EIF3A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
The TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.
TRC8/RNF139 encodes an endoplasmic reticulum-resident E3 ubiquitin ligase that inhibits growth in a RING- and ubiquitylation-dependent manner. TRC8 also contains a predicted sterol-sensing domain. Here, we report that TRC8 protein levels are sterol responsive and that it binds and stimulates ubiquitylation of the endoplasmic reticulum anchor protein INSIG. Induction of TRC8 destabilized the precursor forms of the transcription factors SREBP-1 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID