PFN1
Gene Ontology Biological Process
- negative regulation of actin filament bundle assembly [ISO]
- negative regulation of actin filament polymerization [ISO]
- negative regulation of stress fiber assembly [ISO]
- neural tube closure [IGI]
- positive regulation of ATPase activity [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of viral transcription [ISO]
- regulation of actin polymerization or depolymerization [TAS]
- regulation of transcription from RNA polymerase II promoter [IGI]
- sequestering of actin monomers [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CLTC
Gene Ontology Biological Process
- Golgi organization [ISO]
- mitotic nuclear division [ISO]
- negative regulation of hyaluronan biosynthetic process [ISO]
- negative regulation of protein localization to plasma membrane [ISO]
- osteoblast differentiation [ISO]
- receptor internalization [ISO]
- receptor-mediated endocytosis [ISO]
- spindle assembly involved in mitosis [ISO]
- transferrin transport [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Myb complex [ISO]
- T-tubule [ISO]
- clathrin coat [ISO]
- clathrin complex [ISO]
- clathrin-coated vesicle [ISO]
- cytoplasm [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intracellular membrane-bounded organelle [ISO]
- membrane [ISO]
- membrane coat [IDA]
- mitochondrion [IDA]
- myelin sheath [IDA]
- protein complex [ISO]
- sarcolemma [ISO]
- spindle [ISO]
- terminal bouton [ISO]
- vesicle [ISO]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.
Profilins are thought to be essential for regulation of actin assembly. However, the functions of profilins in mammalian tissues are not well understood. In mice profilin I is expressed ubiquitously while profilin II is expressed at high levels only in brain. In extracts from mouse brain, profilin I and profilin II can form complexes with regulators of endocytosis, synaptic vesicle ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
PFN1 CLTC | Co-fractionation Co-fractionation Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex. | High | 0.8225 | BioGRID | 2667830 |
Curated By
- BioGRID