BAIT
PFN1
Pfn, DN-183N8.15-001
profilin 1
GO Process (15)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- negative regulation of actin filament bundle assembly [ISO]
- negative regulation of actin filament polymerization [ISO]
- negative regulation of stress fiber assembly [ISO]
- neural tube closure [IGI]
- positive regulation of ATPase activity [ISO]
- positive regulation of DNA metabolic process [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of viral transcription [ISO]
- regulation of actin polymerization or depolymerization [TAS]
- regulation of transcription from RNA polymerase II promoter [IGI]
- sequestering of actin monomers [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
HSPA1B
Hsp70, Hsp70-1, Hsp70.1, hsp68
heat shock protein 1B
GO Process (6)
GO Function (1)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.
Profilins are thought to be essential for regulation of actin assembly. However, the functions of profilins in mammalian tissues are not well understood. In mice profilin I is expressed ubiquitously while profilin II is expressed at high levels only in brain. In extracts from mouse brain, profilin I and profilin II can form complexes with regulators of endocytosis, synaptic vesicle ... [more]
EMBO J. Feb. 16, 1998; 17(4);967-76 [Pubmed: 9463375]
Throughput
- Low Throughput
Curated By
- BioGRID