BAIT

SOV1

L000004620, YMR066W
Mitochondrial protein of unknown function
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

RIM101

RIM1, alkaline-responsive transcritional regulator RIM101, L000002818, YHL027W
Cys2His2 zinc-finger transcriptional repressor; involved in alkaline responsive gene repression as part of adaptation to alkaline conditions; involved in cell wall assembly; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by alkaline-dependent proteolytic processing which results in removal of the C-terminal tail; similar to A. nidulans PacC
Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing.

Caballero A, Ugidos A, Liu B, Oeling D, Kvint K, Hao X, Mignat C, Nachin L, Molin M, Nystroem T

Altered mitochondrial functionality can extend organism life span, but the underlying mechanisms are obscure. Here we report that inactivating SOV1, a member of the yeast mitochondrial translation control (MTC) module, causes a robust Sir2-dependent extension of replicative life span in the absence of respiration and without affecting oxidative damage. We found that SOV1 interacts genetically with the cAMP-PKA pathway and ... [more]

Mol. Cell May. 06, 2011; 42(3);390-400 [Pubmed: 21549315]

Throughput

  • High Throughput|Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)
  • phenotype: inviable (APO:0000112)

Additional Notes

  • High Throughput: Synthetic Genetic Array (SGA) analysis
  • Low Throughput: Confirmed using Random Spore Analysis.

Curated By

  • BioGRID