BAIT

SOV1

L000004620, YMR066W
Mitochondrial protein of unknown function
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

RIM8

ART9, PAL3, YGL046W, L000004171, YGL045W
Protein involved in proteolytic activation of Rim101p; part of response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family
UPS Project
GO Process (4)
GO Function (0)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing.

Caballero A, Ugidos A, Liu B, Oeling D, Kvint K, Hao X, Mignat C, Nachin L, Molin M, Nystroem T

Altered mitochondrial functionality can extend organism life span, but the underlying mechanisms are obscure. Here we report that inactivating SOV1, a member of the yeast mitochondrial translation control (MTC) module, causes a robust Sir2-dependent extension of replicative life span in the absence of respiration and without affecting oxidative damage. We found that SOV1 interacts genetically with the cAMP-PKA pathway and ... [more]

Mol. Cell May. 06, 2011; 42(3);390-400 [Pubmed: 21549315]

Throughput

  • High Throughput|Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)
  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • High Throughput: Synthetic Genetic Array (SGA) analysis
  • Low Throughput: Confirmed using Random Spore Analysis.

Curated By

  • BioGRID