BAIT

SOV1

L000004620, YMR066W
Mitochondrial protein of unknown function
GO Process (0)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

ARO2

bifunctional chorismate synthase/riboflavin reductase [NAD(P)H] ARO2, L000000117, YGL148W
Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress
GO Process (2)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Growth Defect

A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.

Publication

Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing.

Caballero A, Ugidos A, Liu B, Oeling D, Kvint K, Hao X, Mignat C, Nachin L, Molin M, Nystroem T

Altered mitochondrial functionality can extend organism life span, but the underlying mechanisms are obscure. Here we report that inactivating SOV1, a member of the yeast mitochondrial translation control (MTC) module, causes a robust Sir2-dependent extension of replicative life span in the absence of respiration and without affecting oxidative damage. We found that SOV1 interacts genetically with the cAMP-PKA pathway and ... [more]

Mol. Cell May. 06, 2011; 42(3);390-400 [Pubmed: 21549315]

Throughput

  • High Throughput|Low Throughput

Ontology Terms

  • vegetative growth (APO:0000106)

Additional Notes

  • High Throughput: Synthetic Genetic Array (SGA) analysis
  • Low Throughput: Confirmed using Random Spore Analysis.
  • Synthetic Sick (SS) phenotype

Curated By

  • BioGRID