DCC
Gene Ontology Biological Process
- apoptotic process [TAS]
- axon guidance [TAS]
- axonogenesis [TAS]
- negative regulation of collateral sprouting [TAS]
- negative regulation of dendrite development [TAS]
- negative regulation of neuron projection development [TAS]
- positive regulation of apoptotic process [TAS]
- regulation of apoptotic process [TAS]
- regulation of neuron death [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
EIF2A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.
Extracellular signals regulate protein translation in many cell functions. A key advantage of control at the translational level is the opportunity to regulate protein synthesis within specific cellular subregions. However, little is known about mechanisms that may link extracellular cues to translation with spatial precision. Here, we show that a transmembrane receptor, DCC, forms a binding complex containing multiple translation ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DCC EIF2A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID