KCNQ1
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [ISO]
- cardiac muscle contraction [ISO]
- cardiovascular system development [ISO]
- cellular response to cAMP [ISO]
- cellular response to drug [ISO]
- gene silencing [ISO]
- male gonad development [IEP]
- membrane repolarization during action potential [ISO]
- membrane repolarization during cardiac muscle cell action potential [ISO]
- negative regulation of insulin secretion [IDA]
- positive regulation of gastric acid secretion [IMP]
- positive regulation of potassium ion transmembrane transport [ISO]
- potassium ion export [ISO]
- potassium ion transmembrane transport [IBA, ISO]
- potassium ion transport [IDA]
- regulation of atrial cardiac muscle cell membrane repolarization [ISO]
- regulation of gene expression by genetic imprinting [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of membrane potential [IDA]
- regulation of membrane repolarization [ISO]
- regulation of ventricular cardiac muscle cell membrane repolarization [ISO]
- response to anesthetic [IDA]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- calmodulin binding [ISO]
- delayed rectifier potassium channel activity [IBA, ISO]
- ion channel binding [ISO]
- outward rectifier potassium channel activity [IDA]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein phosphatase 1 binding [ISO]
- scaffold protein binding [ISO]
- voltage-gated potassium channel activity [ISO]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [ISO]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [ISO]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [ISO]
- calmodulin binding [ISO]
- delayed rectifier potassium channel activity [IBA, ISO]
- ion channel binding [ISO]
- outward rectifier potassium channel activity [IDA]
- potassium channel activity [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase A catalytic subunit binding [ISO]
- protein kinase A regulatory subunit binding [ISO]
- protein phosphatase 1 binding [ISO]
- scaffold protein binding [ISO]
- voltage-gated potassium channel activity [ISO]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [ISO]
- voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization [ISO]
- voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization [ISO]
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.
The KCNQ1 K(+) channel plays a key role in the regulation of several physiological functions, including cardiac excitability, cardiovascular tone, and body electrolyte homeostasis. The metabolic sensor AMP-activated protein kinase (AMPK) has been shown to regulate a growing number of ion transport proteins. To determine whether AMPK regulates KCNQ1, we studied the effects of AMPK activation on KCNQ1 currents in ... [more]
Throughput
- Low Throughput
Additional Notes
- likely ubiquitin conjugate
Curated By
- BioGRID