BAIT
TLR9
CD289, UNQ5798/PRO19605
toll-like receptor 9
GO Process (33)
GO Function (2)
GO Component (13)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IDA]
- defense response to Gram-negative bacterium [IMP]
- defense response to bacterium [NAS]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- maintenance of gastrointestinal epithelium [ISS]
- negative regulation of NF-kappaB transcription factor activity [IDA]
- negative regulation of interleukin-6 production [ISS]
- negative regulation of interleukin-8 production [IDA]
- negative regulation of toll-like receptor signaling pathway [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- positive regulation of JNK cascade [IC]
- positive regulation of JUN kinase activity [IDA]
- positive regulation of NF-kappaB import into nucleus [IDA]
- positive regulation of NF-kappaB transcription factor activity [IDA]
- positive regulation of chemokine production [IDA]
- positive regulation of inflammatory response [IC]
- positive regulation of interferon-alpha biosynthetic process [IDA]
- positive regulation of interferon-beta biosynthetic process [IDA]
- positive regulation of interferon-beta production [ISS]
- positive regulation of interferon-gamma biosynthetic process [IDA]
- positive regulation of interleukin-10 production [ISS]
- positive regulation of interleukin-12 production [ISS]
- positive regulation of interleukin-18 production [ISS]
- positive regulation of interleukin-6 production [IDA]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of nitric-oxide synthase biosynthetic process [ISS]
- positive regulation of toll-like receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of tumor necrosis factor production [ISS]
- response to molecule of bacterial origin [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [TAS]
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- cytoplasm [IDA]
- early phagosome [ISS]
- endolysosome membrane [TAS]
- endoplasmic reticulum [ISS]
- endoplasmic reticulum membrane [TAS]
- endosome [ISS]
- endosome membrane [TAS]
- extracellular region [NAS]
- lysosome [ISS]
- plasma membrane [IDA]
Homo sapiens
PREY
STUB1
CHIP, HSPABP2, NY-CO-7, SCAR16, SDCCAG7, UBOX1, LA16c-313D11.6
STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
GO Process (15)
GO Function (15)
GO Component (10)
Gene Ontology Biological Process
- cellular response to misfolded protein [IDA]
- misfolded or incompletely synthesized protein catabolic process [IDA]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- positive regulation of chaperone-mediated protein complex assembly [IDA]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein ubiquitination [IDA]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]
- protein K63-linked ubiquitination [IDA]
- protein autoubiquitination [IDA]
- protein maturation [TAS]
- protein polyubiquitination [IDA, IMP]
- regulation of glucocorticoid metabolic process [IDA]
- transforming growth factor beta receptor signaling pathway [TAS]
- ubiquitin-dependent SMAD protein catabolic process [IDA]
- ubiquitin-dependent protein catabolic process [IMP]
Gene Ontology Molecular Function- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- SMAD binding [IDA]
- TPR domain binding [IDA]
- enzyme binding [IPI]
- kinase binding [IPI]
- misfolded protein binding [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [ISS]
- ubiquitin protein ligase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA, IMP, TAS]
- ubiquitin-ubiquitin ligase activity [ISS]
- G-protein coupled receptor binding [IPI]
- Hsp70 protein binding [IDA]
- Hsp90 protein binding [IDA]
- SMAD binding [IDA]
- TPR domain binding [IDA]
- enzyme binding [IPI]
- kinase binding [IPI]
- misfolded protein binding [IDA]
- protein binding [IPI]
- protein binding, bridging [TAS]
- protein homodimerization activity [ISS]
- ubiquitin protein ligase activity [IDA]
- ubiquitin protein ligase binding [IPI]
- ubiquitin-protein transferase activity [IDA, IMP, TAS]
- ubiquitin-ubiquitin ligase activity [ISS]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}.
The carboxyl terminus of constitutive heat shock cognate 70 (HSC70)-interacting protein (CHIP, also known as Stub1) is a U box-containing E3 ubiquitin ligase that is important for protein quality control. The role of CHIP in innate immunity is not known. Here, we report that CHIP knockdown inhibits Toll-like receptor (TLR) 4- and TLR9-driven signaling, but not TLR3-driven signaling; proinflammatory cytokine ... [more]
J. Exp. Med. Sep. 26, 2011; 208(10);2099-112 [Pubmed: 21911421]
Throughput
- Low Throughput
Curated By
- BioGRID