MIB1
Gene Ontology Biological Process
Gene Ontology Molecular Function
DLL1
Gene Ontology Biological Process
- Notch receptor processing [TAS]
- Notch signaling pathway [IMP, NAS, TAS]
- cell differentiation [TAS]
- cell fate determination [NAS]
- determination of left/right symmetry [ISS]
- heart looping [ISS]
- hemopoiesis [NAS]
- negative regulation of interleukin-10 production [IMP]
- neuronal stem cell maintenance [IEP]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of cell adhesion [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Delta-like 1-Lysine613 regulates notch signaling.
Delta ligands are important for regulating Notch signaling through transcellular stimulation of Notch receptors. The cytoplasmic tails of Delta ligands have multiple potential regulatory sites including several lysine residues that are putative targets for ubiquitination by the E3 ubiquitin ligases, Mind Bomb and Neuralized. To identify possible roles for specific lysine residues in the cytoplasmic tail of the Notch ligand ... [more]
Throughput
- Low Throughput
Additional Notes
- source of MIB1 not clear
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DLL1 MIB1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID