MIB2
Gene Ontology Biological Process
Gene Ontology Molecular Function
BCL10
Gene Ontology Biological Process
- B cell apoptotic process [IDA, IMP]
- I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- T cell apoptotic process [IDA, IMP]
- T cell receptor signaling pathway [ISO]
- activation of JUN kinase activity [ISA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISA]
- cell death [ISO]
- cellular defense response [IMP]
- fibroblast apoptotic process [IMP]
- immunoglobulin mediated immune response [IMP]
- mast cell activation [NAS]
- negative regulation of mature B cell apoptotic process [ISO]
- neural tube closure [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISA]
- positive regulation of T cell activation [IMP]
- positive regulation of apoptotic process [ISA, ISO]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of execution phase of apoptosis [ISO]
- positive regulation of extrinsic apoptotic signaling pathway [IDA, ISO]
- positive regulation of interleukin-8 biosynthetic process [ISO]
- positive regulation of phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein heterooligomerization [ISO]
- protein homooligomerization [IMP]
- protein oligomerization [ISO]
- regulation of T cell receptor signaling pathway [IMP]
- response to food [ISO]
- response to fungus [IMP]
- thymocyte apoptotic process [IMP]
Gene Ontology Molecular Function- NF-kappaB binding [IBA, ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISA]
- enzyme binding [ISO]
- kinase activator activity [ISO]
- kinase binding [ISO]
- protease binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISA]
- protein homodimerization activity [ISA]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- NF-kappaB binding [IBA, ISO]
- cysteine-type endopeptidase activator activity involved in apoptotic process [ISA]
- enzyme binding [ISO]
- kinase activator activity [ISO]
- kinase binding [ISO]
- protease binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISA]
- protein homodimerization activity [ISA]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- protein self-association [ISO]
- transcription coactivator activity [ISO]
- transcription factor binding [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- CBM complex [IBA]
- T cell receptor complex [ISO]
- cytoplasm [IDA, ISA, ISO]
- cytoplasmic microtubule [ISO]
- cytosol [IDA, ISO]
- immunological synapse [IDA]
- intracellular [IMP]
- lipopolysaccharide receptor complex [ISO]
- lysosome [ISO]
- membrane raft [IDA]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- protein complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The E3 Ubiquitin Ligase Mind Bomb-2 (MIB2) Protein Controls B-cell CLL/Lymphoma 10 (BCL10)-dependent NF-{kappa}B Activation.
B-cell CLL/lymphoma 10 (BCL10) is crucial for the activation of NF-κB in numerous immune receptor signaling pathways, including the T-cell receptor (TCR) and B-cell receptor signaling pathways. However, the molecular mechanisms that lead to signal transduction from BCL10 to downstream NF-κB effector kinases, such as TAK1 and components of the IKK complex, are not entirely understood. Here we used a ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID