IKBKB
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- I-kappaB phosphorylation [IDA, TAS]
- cellular response to tumor necrosis factor [ISO]
- neuron projection development [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of cation channel activity [IGI]
- positive regulation of cell proliferation [ISO]
- positive regulation of neuron death [ISO]
- positive regulation of sodium ion transport [IGI]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- protein phosphorylation [IMP, ISO]
- serine phosphorylation of STAT protein [ISO]
- signal transduction by phosphorylation [TAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- IkappaB kinase activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- receptor signaling protein serine/threonine kinase activity [TAS]
- scaffold protein binding [ISO]
- ATP binding [ISO]
- IkappaB kinase activity [IDA]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase activity [IDA, IMP, ISO]
- protein kinase binding [ISO]
- receptor signaling protein serine/threonine kinase activity [TAS]
- scaffold protein binding [ISO]
Gene Ontology Cellular Component
NKX3-2
Gene Ontology Biological Process
- determination of left/right symmetry [IMP]
- digestive system development [IMP]
- embryonic skeletal system development [IMP]
- intestinal epithelial cell development [IGI]
- middle ear morphogenesis [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of chondrocyte differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- organ development [IMP]
- organ formation [IMP]
- pancreas development [IMP]
- skeletal system development [IMP]
- skeletal system morphogenesis [IMP]
- spleen development [IMP]
- transcription from RNA polymerase II promoter [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Exogenous signal-independent nuclear IkappaB kinase activation triggered by Nkx3.2 enables constitutive nuclear degradation of IkappaB-alpha in chondrocytes.
NF-κB is a multifunctional transcription factor involved in diverse biological processes. It has been well documented that NF-κB can be activated in response to various stimuli. While signal-inducible NF-κB activation mechanisms have been extensively characterized, exogenous signal-independent intrinsic NF-κB activation processes remain poorly understood. Here we show that IκB kinase β (IKKβ) can be intrinsically activated in the nucleus by ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NKX3-2 IKBKB | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| IKBKB NKX3-2 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 569358 |
Curated By
- BioGRID