NR1D1
Gene Ontology Biological Process
- cellular response to lipopolysaccharide [IMP]
- circadian regulation of gene expression [ISS]
- circadian temperature homeostasis [ISS]
- gene expression [TAS]
- glycogen biosynthetic process [ISS]
- intracellular receptor signaling pathway [TAS]
- negative regulation of receptor biosynthetic process [IMP]
- negative regulation of toll-like receptor 4 signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of bile acid biosynthetic process [ISS]
- positive regulation of cholesterol homeostasis [IDA]
- positive regulation of transcription, DNA-templated [ISS]
- proteasomal protein catabolic process [ISS]
- regulation of cholesterol homeostasis [ISS]
- regulation of circadian rhythm [ISS]
- regulation of fat cell differentiation [ISS]
- regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of insulin secretion involved in cellular response to glucose stimulus [ISS]
- regulation of lipid metabolic process [ISS]
- regulation of type B pancreatic cell proliferation [ISS]
- response to leptin [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [IDA]
- heme binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- protein binding [IPI]
- transcription corepressor activity [TAS]
- transcription corepressor binding [IDA, IMP]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IMP]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- core promoter sequence-specific DNA binding [IDA]
- heme binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [TAS]
- protein binding [IPI]
- transcription corepressor activity [TAS]
- transcription corepressor binding [IDA, IMP]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
NCOR1
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- negative regulation of JNK cascade [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IMP, TAS]
- regulation of fatty acid transport [IC]
- regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [IMP]
- small molecule metabolic process [TAS]
- spindle assembly [IMP]
- transcription from RNA polymerase II promoter [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
High throughput analysis of protein-protein interactions is an important sector of hypothesis-generating research. Using an improved and automated version of the yeast two-hybrid system, we completed a large interaction screening project with a focus on nuclear receptors and their cofactors. A total of 425 independent yeast two-hybrid cDNA library screens resulted in 6425 potential interacting protein fragments involved in 1613 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| NCOR1 NR1D1 | Phenotypic Enhancement Phenotypic Enhancement A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | - |
Curated By
- BioGRID