BAIT
ATXN7
ADCAII, OPCA3, SCA7
ataxin 7
GO Process (5)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
AGRN
CMSPPD, RP11-54O7.13-009
agrin
GO Process (19)
GO Function (8)
GO Component (9)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [TAS]
- axon guidance [TAS]
- carbohydrate metabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- clustering of voltage-gated sodium channels [TAS]
- extracellular matrix organization [TAS]
- glycosaminoglycan biosynthetic process [TAS]
- glycosaminoglycan catabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- phototransduction, visible light [TAS]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of filopodium assembly [ISS]
- positive regulation of synaptic growth at neuromuscular junction [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- receptor clustering [IDA, IMP]
- retinoid metabolic process [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
- synapse organization [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.
Spinocerebellar ataxias 6 and 7 (SCA6 and SCA7) are neurodegenerative disorders caused by expansion of CAG repeats encoding polyglutamine (polyQ) tracts in CACNA1A, the alpha1A subunit of the P/Q-type calcium channel, and ataxin-7 (ATXN7), a component of a chromatin-remodeling complex, respectively. We hypothesized that finding new protein partners for ATXN7 and CACNA1A would provide insight into the biology of their ... [more]
Hum. Mol. Genet. Feb. 01, 2011; 20(3);510-27 [Pubmed: 21078624]
Throughput
- Low Throughput
Curated By
- BioGRID