ATXN7
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MEGF8
Gene Ontology Biological Process
- BMP signaling pathway [ISS]
- cell migration involved in gastrulation [IMP]
- craniofacial suture morphogenesis [IMP]
- determination of digestive tract left/right asymmetry [ISS]
- determination of heart left/right asymmetry [IMP]
- embryonic heart tube left/right pattern formation [ISS]
- embryonic heart tube morphogenesis [ISS]
- embryonic limb morphogenesis [ISS]
- embryonic skeletal system morphogenesis [ISS]
- epiboly involved in gastrulation with mouth forming second [IMP]
- fasciculation of sensory neuron axon [ISS]
- left/right pattern formation [IMP]
- limb morphogenesis [IMP]
- positive regulation of axon extension involved in axon guidance [ISS]
- regulation of gene expression [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.
Spinocerebellar ataxias 6 and 7 (SCA6 and SCA7) are neurodegenerative disorders caused by expansion of CAG repeats encoding polyglutamine (polyQ) tracts in CACNA1A, the alpha1A subunit of the P/Q-type calcium channel, and ataxin-7 (ATXN7), a component of a chromatin-remodeling complex, respectively. We hypothesized that finding new protein partners for ATXN7 and CACNA1A would provide insight into the biology of their ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ATXN7 MEGF8 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID