BAIT
CACNA1A
APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- calcium ion import [IBA]
- cell death [IDA]
- energy reserve metabolic process [TAS]
- membrane depolarization [TAS]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [IDA, ISS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ABCA2
ABC2, RP11-229P13.8
ATP-binding cassette, sub-family A (ABC1), member 2
GO Process (9)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- cholesterol homeostasis [IEP]
- lipid metabolic process [NAS]
- regulation of intracellular cholesterol transport [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- response to drug [TAS]
- response to steroid hormone [IEP]
- transmembrane transport [NAS]
- transport [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.
Spinocerebellar ataxias 6 and 7 (SCA6 and SCA7) are neurodegenerative disorders caused by expansion of CAG repeats encoding polyglutamine (polyQ) tracts in CACNA1A, the alpha1A subunit of the P/Q-type calcium channel, and ataxin-7 (ATXN7), a component of a chromatin-remodeling complex, respectively. We hypothesized that finding new protein partners for ATXN7 and CACNA1A would provide insight into the biology of their ... [more]
Hum. Mol. Genet. Feb. 01, 2011; 20(3);510-27 [Pubmed: 21078624]
Throughput
- Low Throughput
Curated By
- BioGRID