BAIT
CACNA1A
APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
GO Process (9)
GO Function (4)
GO Component (5)
Gene Ontology Biological Process
- calcium ion import [IBA]
- cell death [IDA]
- energy reserve metabolic process [TAS]
- membrane depolarization [TAS]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [IDA, ISS]
- regulation of insulin secretion [TAS]
- small molecule metabolic process [TAS]
- synaptic transmission [IBA, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PCSK5
PC5, PC6, PC6A, SPC6, RP11-422N19.4
proprotein convertase subtilisin/kexin type 5
GO Process (18)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- anterior/posterior pattern specification [IMP]
- cell-cell signaling [TAS]
- cytokine biosynthetic process [ISS]
- embryo implantation [ISS]
- embryonic digestive tract development [IMP, ISS]
- embryonic skeletal system development [IMP, ISS]
- heart development [ISS]
- kidney development [IMP, ISS]
- limb morphogenesis [ISS]
- nerve growth factor processing [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptide biosynthetic process [IDA]
- peptide hormone processing [IDA]
- protein processing [IDA]
- renin secretion into blood stream [IEP]
- respiratory tube development [ISS]
- signal peptide processing [IDA]
- viral life cycle [IEP, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.
Spinocerebellar ataxias 6 and 7 (SCA6 and SCA7) are neurodegenerative disorders caused by expansion of CAG repeats encoding polyglutamine (polyQ) tracts in CACNA1A, the alpha1A subunit of the P/Q-type calcium channel, and ataxin-7 (ATXN7), a component of a chromatin-remodeling complex, respectively. We hypothesized that finding new protein partners for ATXN7 and CACNA1A would provide insight into the biology of their ... [more]
Hum. Mol. Genet. Feb. 01, 2011; 20(3);510-27 [Pubmed: 21078624]
Throughput
- Low Throughput
Curated By
- BioGRID